Lipids and Lipid Derivatives
Medchemexpress LLC C20 Ceramide | 7344-02-7 | 99.1% | 594.01 | 1 MG
C20 Ceramide (N-Arachidoyl-D-sphingosine) is a natural 20:0 ceramide and an N-acylsphingosine where the ceramide N-acyl group is eicosanoyl. It acts as a key signal molecule mediating biological processes such as cell growth, differentiation, senescence, and apoptosis. This product is for research use only.
- Natural 20:0 ceramide and N-acylsphingosine
- Acts as a key signal molecule mediating biological processes
- Mediates cell growth, differentiation, senescence, and apoptosis
Cayman Chemical C8 Ceramide-1-phosphate (d18:1/8:0) (ammonium salt), Purity: ≥90%, CAS: 474943-70-9, 10 mg
C8 ceramide-1-phosphate is a short-chain analog of the naturally occurring ceramide-1-phosphate. The effects of C8 ceramide-1-phosphate are essentially the opposite of C8 ceramide; it induces DNA synthesis and cell division. The effects of C8 ceramide-1-phosphate can be attenuated by simultaneous treatment with C2 or C8 ceramide.{5183}
Medchemexpress LLC C26-ceramide | 121459-09-4 | MFCD18379264 | 99.9% | 678.17 g/mol | C44H87NO3 | 1 MG
C26-Ceramide is a very long-chain ceramide lipid consisting of a sphingoid base N-acylated with a C26 fatty acid. It is supplied as a high-purity biochemical reagent for lipid research and formulation work, including development of lipid nanoparticles and liposomes.
- Very long-chain ceramide with one saturated and one unsaturated hydrophobic tail.
- High purity (approximately 99.9%) suitable for analytical and formulation studies.
- Molecular weight 678.17 g/mol; chemical formula C44H87NO3.
- Supplied in small research quantities (example: 1 mg) for experimental use.
- Stable as a powder when stored at -20 °C; follow laboratory handling and storage guidelines.
Sigma Aldrich Fine Chemicals Biosciences Colorimetric Sphingomyelin
Sphingomyelinase (SMase) or sphingomyelin phosphodiesterase catalyzes the hydrolytic cleavage of sphingolipid to phosphocholine and ceramide a second messenger involved in multiple cellular responses including the cellular response to stress. There are at least 5 types of SMases identified which are classified according to their cation dependence cellular location and pH optima for activity and include the acidic and neutral sphingomyelinase. Neutral SMases along with the acidic SMases are thought to be major contributors to the production of ceramide in response to cellular stress.
Medchemexpress LLC N-Behenoyl-D-erythro-sphingosine | 27888-44-4 | MFCD09840213 | 98.0% | 622.06 g/mol | C40H79NO3 | 10 MG
C22-Ceramide (N-Behenoyl-D-erythro-sphingosine) is an endogenous bioactive sphingolipid used in research on membrane dynamics and mitochondrial ceramide channel formation. It reduces the propensity of C16-ceramide channel formation in isolated rat liver mitochondria and in liposomes. Supplied as a solid white to off-white powder with high purity for analytical and biological studies.
- Endogenous bioactive sphingolipid relevant to membrane and apoptosis studies.
- Reduces propensity of C16-ceramide channel formation in mitochondria and liposomes.
- White to off-white solid suitable for handling and formulation.
- Purity 98.0% for reproducible experimental results.
- Molecular formula C40H79NO3; molecular weight 622.06 g/mol.
- Soluble in ethanol and DMF using ultrasonic and warming up to 60°C as needed.
- Store at 4°C protected from light; in solution keep at -80°C (up to 6 months) or -20°C (up to 1 month).
Cambridge Isotope Laboratories Lyso-PC 20 0 (unlabeled) CP 95% 5 mg
Lyso-PC 20 0 (unlabeled) CP 95% 5 mg
Cayman Chemical C16 Sphingomyelin (d18:1/16:0), Purity: ≥98%, CAS: 6254-89-3, 5 mg
A naturally occurring sphingolipid; levels are elevated in the prefrontal cortex and cerebellum in a rat model of STZ-induced diabetes, as well as in the liver in mouse models of Niemann-Pick type C1 disease; plasma are decreased in patients with prostate cancer; has been used in model membranes with POPC and cholesterol in the study of lipid raft dynamics and membrane organization
Cayman Chemical C16 Ceramide (d18:1/16:0), Purity: ≥98%, CAS: 24696-26-2, 25 mg
A sphingolipid; levels are increased by PPMP or MAPP in isolated human neutrophils and are correlated with an increase in apoptosis; accumulates in the lungs of patients with cystic fibrosis compared with the lungs of patients with pulmonary hypertension; plasma levels are increased in patients with acute coronary syndrome, and an increased plasma ratio of C16 to C24:0 ceramide is associated with major adverse cardiac events; levels are increased in tumor tissue from patients with breast cancer and is associated with metastatic cancer
Medchemexpress LLC N-Behenoyl-D-erythro-sphingosine | 27888-44-4 | C40H79NO3 | 1 MG
C22-Ceramide, also known as N-Behenoyl-D-erythro-sphingosine, is an endogenous bioactive sphingolipid. This compound has been observed to reduce the propensity of C16-ceramide channel formation in isolated rat liver mitochondria and in liposomes. It is primarily intended for research use.
- Endogenous bioactive sphingolipid
- Reduces C16-ceramide channel formation
- Potential for research into intrinsic apoptosis regulation
Medchemexpress LLC Sphingomyelin | 85187-10-6 | ≥99.0% | 10 MG
Sphingomyelin is a eukaryotic sphingolipid and a primary component of cell membranes, especially abundant in the myelin sheath surrounding neuronal axons. It is significant in cell processes, regulating inflammatory responses, and signal transduction. Its metabolism is linked to various central nervous system diseases and Niemann-Pick disease.
- Eukaryotic sphingolipid
- Major constituent of cell membranes
- Abundant in myelin sheath
- Involved in cell processes
- Regulates inflammatory responses
- Involved in signal transduction
- Metabolism linked to central nervous system diseases and Niemann-Pick disease
- Metabolism produces interconvertible bioactive sphingolipids
- Enriches lipid raft-mediated cell signaling
Medchemexpress LLC C12-NBD Sphinganine | 474943-05-0 | 99.9% | C36H63N5O6 | 1 MG
C12-NBD Sphinganine is a fluorescent ceramidase substrate that can be used for the measurement of alkaline and neutral ceramidase activity from a variety of sources.
- Fluorescent ceramidase substrate
- Used for measuring alkaline and neutral ceramidase activity
- Molecular weight: 661.92
- Appearance: Solid
- Color: Light yellow to yellow
- Recommended storage at -20°C, sealed, away from moisture and light
- In solvent, stable for 6 months at -80°C or 1 month at -20°C
Medchemexpress LLC C16 PEG2000 Ceramide | 212116-78-4 | 99.4% | (C2H4O)nC39H73NO6 | 50 MG
C16 PEG2000 Ceramide is a polyethylene glycolylated ceramide that functions as a lipid carrier for delivery. It induces autophagy and is suitable for cancer research.
- Functions as a lipid carrier for delivery
- Induces autophagy
- Suitable for cancer research
- Exhibits cytotoxicity in N2a cells
- Promotes autophagy in N2a cells
- Increases LC3-II/LC3-I ratios in N2a cells
- Reduces WT-Tau and P301L-Tau proteins in N2a cells
Medchemexpress LLC Sphingomyelin Syntha 10ug
The sphingomyelin synthase 2 (SGMS2) protein plays a crucial role in plasma membrane sphingomyelin synthesis It catalyzes the reversible transfer of the phosphocholine moiety in sphingomyelin biosynthesis to form ceramide phosphocholine Sphingomyelin Synthase 2/SGMS2 Protein Human (HEK293 Fc) is the recombinant human-derived Sphingomyelin Synthase 2/SGMS2 protein expressed by HEK293 with N-mFc labeled tag